LARGE-CELL SPLENOMEGALY (GAUCHERʼS DISEASE)

Massive splenomegaly in hairy cell leukemia.

n engl j med 367;22 nejm.org november 29, 2012 2133 A 63-year-old man presented with a 6-month history of fatigue, weight loss, and gingival bleeding. Physical examination suggested the presence of a massively enlarged spleen, a finding confirmed on a reconstructed coronal computed tomographic image of the abdomen (Panel A, arrowheads). A complete blood count revealed thrombocytopenia (platelet...

Splenomegaly, hypersplenism, and hereditary disorders with splenomegaly

Splenomegaly, sometimes of massive extent, occurs in a large number of hereditary diseases, some relatively prevalent and others, rare to ultra-rare. Because physicians are often unfamiliar with the less common disorders, patients may suffer because of diagnostic delay or diagnostic error and may undergo invasive, non-innocuous procedures such as splenectomy that are potentially avoidable were ...

Sickle cell disease and hyperreactive malarial splenomegaly (HMS) in young immigrants from Africa.

patient 2112 is in continued complete remission (CCR; 61 ). Interestingly, patient 1179 showed no FLT3/ITD mutation at relapse (Figure 1C), possibly due to loss of the mutated allele during therapy, or, alternatively, the FLT3/ITD-positive clone was eliminated during chemotherapy with a subsequent relapse from a non–FLT3-mutated parental clone. In conclusion, we confirm the presence of FLT3 mut...

Gaucher’s Disease, an Unusual Cause of Massive Splenomegaly, a Case Report

Background Gaucher’s Disease (G.D.) is an autosomal recessive disorder resulting from the accumulation of glucocerebrosidase in the cells of macrophage-monocyte system as a result of a deficiency in lysosomal glucocerebrosidase. This enzyme is encoded by a gene on chromosome-1. Here we report a case of Gaucher’s Disease .G.D is rare in Yazd. Case reports We reported a patient that presented...

Bengal Splenomegaly